Arnold Lab

Transfer of cell surface proteins via EV to induce pathological cell function

Our research group is dedicated to exploring the role of extracellular vesicles (EVs) for the transfer of cell surface receptors and enzymes. We are particularly interested how the transfer of these cell surface receptors and enzymes changes cell signaling and cell homeostasis on the recipient cell and how this induces physiological and pathological cell function. We are particularly working to better understand mechanisms that intersect at inflammation, cancer and fibrosis. With their central role for inter-cellular and inter-organ communication EV might contribute to the induction, proliferation and dissemination of tumors and may play a pivotal role in the transmission of pro-inflammatory signals across the body. For EV enrichment from cell culture supernatant or patient serum, we use precipitation, ultracentrifugation or gel-filtration methods. Besides characterization with biochemical and biophysical methods, our expertise lies in transmission electron microscopy (TEM), which we use for EV imaging and analysis.

Principal Investigator:

PD Dr. rer. nat. Dr. habil. med. Philipp Arnold

Independent group leader