Baur/Van Deun Lab

Blood-derived EVs as a window into systemic inflammatory processes

We aim to understand the characteristics and interactions of blood-borne EVs in the human body, to develop novel biomarkers and therapeutics. To this end, we focus both on EVs derived directly from blood plasma, as well as from primary blood cells. Through rigorous biochemical and physical phenotyping of EV populations, we aim to improve diagnosis, prognosis and monitoring of disease. One of our core topics of interest is mapping the endogenous protease activity of circulating EVs in different conditions, including cancer (melanoma, lymphoma, prostate, among others), autoimmune disease and neurodegeneration (Alzheimer’s, Long Covid). To accelerate clinical translation, we develop robust EV isolation and analysis workflows, including through automation and interdisciplinary collaborations (e.g. with Sandoghdar Lab, MPI for the Science of Light).

More info on www.kivesd-projekt.de.

Principal Investigators:

Dr. Jan Van Deun

Project Leader

Prof. Dr. med. Andreas Baur

Professor of Dermatology