Müller Lab

Chronic rhinosinusitis with nasal polyp (CRSwNP) Extracellular Vesicles (EVs)

Our research group is investigating the pathogenesis of chronic rhinosinusitis by highlighting the role of extracellular vesicles (EVs), specifically in chronic rhinosinusitis with nasal polyp (CRSwNP). We explore how EVs facilitate the cell-cell communication by an interepithelial transfer of pathological cargo.

The EVs carry some key inflammatory biomarkers hypothesizing the promotion of polyp growth and chronic inflammation through the spreads of inflammatory signals to otherwise healthy nasal tissue. The EVs isolated from nasal mucosa of CRSwNP patients and from primary epithelial cells derived from nasal polyp are analyzed by using advanced technics such as Air-liquide-interface (ALI) culture, ELISA, TEM…

Our objective is to reveal new insights about the pathogenesis of CRSwNP and identify potential targets for future therapies.

Principal Investigator:

Prof. Dr. Sarina Müller

Head of the Department of Otorhinolaryngology